5-Amino-1MQ 50mg Kit

5-Amino-1MQ (5-amino-1-methylquinolinium) is a synthetic small molecule that selectively inhibits Nicotinamide N-methyltransferase (NNMT). NNMT is an enzyme that methylates nicotinamide (vitamin B3) using S-adenosylmethionine (SAM) as a methyl donor. In states of obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and reducing NAD+ availability.

By inhibiting NNMT, 5-Amino-1MQ may spare nicotinamide for NAD+ synthesis, thereby activating SIRT1 (Sirtuin 1) pathways associated with mitochondrial biogenesis and fat oxidation. Preclinical studies indicate that NNMT knockdown or inhibition can protect against diet-induced weight gain and improve metabolic parameters without reducing food intake.

Complementary strategies for best outcomes.

• Pair with a balanced, protein-forward diet tailored to energy needs.
• Combine resistance training and aerobic activity—preclinical data suggest synergy with exercise.
• Prioritise sleep and stress management to support metabolic adaptation.
• Consider complementary NAD+ precursors (NMN/NR) per emerging stack protocols.

  Key Benefits

  Observations from preclinical and early research literature.

  • May support reductions in fat mass while preserving lean muscle in animal models.
  • Associated with elevated NAD+ levels and SIRT1 activation in preclinical studies.
  • Enhanced grip strength observed in aged mice when combined with exercise.
  • Generally well tolerated; occasional reports of mild headache, transient jitteriness, or injection-site reactions.
  • Long-term human safety data not established; this compound remains investigational.